About the Program
Here at the Integrated Neuroscience and Treatment Program, we seek to advance the understanding of cognitive and neural mechanisms underlying cognitive control and their impairments in serious mental illness such as schizophrenia. Cognitive control describes the ability to coordinate and appropriately bias cognitive processes in the service of goal-directed behavior. Our research investigates the neural basis of these top-down influences and how they are dynamically adjusted in response to the impact of stimulus and response history, changes in attentional state, and updates in task demands.
- Prefrontal cortical engagement elicited by transcranial direct current stimulation (tDCS) in individuals with Schizophrenia
- Impact on long-acting injectables versus oral antipsychotics in disease progression in Schizophrenia
One primary focus of our research examines the role of synchronous, oscillatory neuronal activity in supporting cognitive control and sensory processes. For instance, gamma-band oscillations, in coordination with brain rhythms in other frequency bands, have been associated with basic perception as well as higher-order cognitive processes such as attention and working memory. Our understanding of such basic neural mechanisms in normal cognition informs our study of cognitive disturbance in schizophrenia and related disorders, where such impairments give rise to significant functional debilitation. We use multimodal imaging (EEG, MRS and fMRI), computational modeling and noninvasive neurostimulation (tDCS, tACS, TMS) to probe and modulate these brain mechanisms with the aim of developing novel therapeutics for cognitive disturbances in neuropsychiatric illness.