Pumin Zhang Lab



Zhang, P. and Li, M. (1989). Dynamics of plasma abnormal prothrombin during the process of hepatocarcinogenesis in rats. Acta Academiae Medicinae Shanghai 16, 187-190.

Zhang, P. and Li, M. (1989). Studies on abnormal prothrombin in rats with hepatocarcinoma. Chinese Biochemical J. 5, 199-203.

Shah, D. V., Zhang, P., Engelke, E. A. and Suttie. J. W. 1993. Vitamin K-dependent carboxylase activity, prothrombin mRNA and prothrombin production in two cultured rat hepatoma cell lines. Thrombosis Res. 70, 365-373.

Zhang, P. and Suttie, J. W. (1994). Prothrombin synthesis and degradation in rat hepatoma (H-35) cells: effects of warfarin. Blood 84, 169-175.

Harper, J. W., Elledge, S. J., Keyomarsi, K., Dynlacht, B., Tsai, L-H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., Swindell, E., Fox,M. P., Wei, N. (1995). Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6, 387-400.

Matsuoka, S., Edwards, M., Bai, C., Parker, S. B., Zhang, P., Baldini, A., Harper, J.W., Elledge, S. J. (1995). p57, a structurally distinct member of the p21Cip1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9, 650-662.

Parker, S. B., Eichele, G., Zhang, P., Rawls, A., Sands, A. T., Bradley, A., Olson, E. N., Harper, J. W. and Elledge, S. J. (1995). p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267, 1024-1027.

Deng, C., Zhang, P., Harper, J. W., Elledge, S. J. and Leder, P. 1995. Mice lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684.

Zhang, P., Liegeois, N. J., Wang, C., Finegold, M., Hou, H., Thompson, J. C., Silverman, A., Harper, J. W., DePinho, R. A. and S. J. Elledge. (1997). Altered cellular differentiation and proliferation in mice lacking p57 indicates a role in Beckwith-Wiedemann Syndrome. Nature 387, 151-158.

Zhang, P., Wang, C., Harper, J. W., R. A. DePinho and S. J. Elledge. (1998). Cooperation between the Cdk Inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development. Genes Dev. 12, 3162-7.

Zhang, P., Wang, C., Liu, D., Finegold, M., Harper, J. W., and S. J. Elledge. (1999). p21CIP1 and p57KIP2 control the development of skeletal muscle at myogenin step. Genes Dev. 13, 213-224.

Zhang, P. (1999). Cell cycle control and development: redundant roles of cell cycle regulators. Curr. Opin. Cell Biol. 11, 655-662.

Lahoz, E. G., Liegeois, N. J., Zhang, P., Engelman, J. A, Horner, J., Silverman, J., Burde, R., Roussel, M. F., Sherr, C. J., Elledge, S. J, and R. A. DePinho. (1999). Cyclin D- and E-dependent kinases and the p57 inhibitor: cooperative interactions in vivo. Mol. Cell. Biol. 19:353-363.

Caspary, T., Cleary, M. A., Perlman, E. J., Zhang, P., Elledge, S. J. and S. M. Tilghman. (1999) Oppositely imprinted genes p57Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome Genes Dev. 13, 3115-3124.

Mei, J., Huang, X. and Zhang, P. (2001). Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr. Biol. 11, 1197-1201.

Hiromura, K., Haseley, L. A., Zhang, P., Monkawa, T., Durvasula, R., Petermann, A. T., Alpers, C. E. , Mundel, P., and Shankland, S. J. (2001). Podocyte expression of the CDK-inhibitor p57 during development and disease. Kidney Int. 60, 2235-2246.

Zhang, P., Liu, M., and Elledge, S. (2002). Towards genetic genome projects: genomic library screening and gene targeting vector construction in a single step. Nature Genet. 30, 31-39.

Delgado, I., Huang, X, Jones, S., Zhang, L., Hatcher, L., Gao, B. and Zhang, P. (2003). Dynamic gene expression during the onset of myoblast differentiation in vitro. Genomics 82, 109-121.

Griep, A.E. and Zhang, P. (2004). Lens Cell Proliferation: The Cell Cycle in Development of the Ocular Lens. F.J. Lovicu and M.L. Robinson, editors. Cambridge University Press, Cambridge, UK. 191-214.

Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ. (2004). Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci USA. 101: 3338-45

MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM. (2004) The cyclin-dependent kinase inhibitor p57 (Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest. 113:1334-43.

Huang, X., Tran, T., Zhang, L., Hatcher, R., Zhang, P. (2005). DNA damage induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci USA. 102:1065-70.

Huang, X., Hatcher, R., York, J.P., and Zhang, P. (2005). Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell 16: 4725-32

Peng, X., York, J.P., and Zhang, P. (2006). A transgenic approach for RNA interference-based genetic screening in mice. Proc Natl Acad Sci USA 103, 2252-2256.

Chelu, M.G., Sanjeewa A. Goonasekera, S.A., Durham, W.J., Wei Tang1, W., Lueck, J.D., Joyce Riehl, J., Pessah, I.N., Zhang, P., Bhattacharjee, M.B., Dirksen, R.T. and Hamilton, S.L. (2006). A Mouse RyR1 Mutation associated with heat- and anesthesia-induced malignant hyperthermia. FASEB J. 20: 329-330.

Georgia, S., Li, M., Zhang, P.*, and Bhushan, A*. (2006). p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev. Biol. 298, 22-31. (* corresponding authors).

Li, M., York, J. P., and Zhang, P. (2007). Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol. Cell Biol. 27, 3481-8.

Jia, J., Li, M., Zhang, L., York, J. P., and Zhang, P. (2007) The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol. Cell Biol. 27, 7236-47.

Gao, X. and Zhang, P. (2007). Transgenic RNA interference in mice. Physiology 22: 161-166.

Jin, R. J., Lho, Y., Wang, Y., Ao, M., Revelo, M. P., Hayward, S. W., Wills, M.L., Logan, S. K., Zhang, P., and Matusik, R. J. (2008). Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res. 68, 3601-08.

Zhang, J., Shi, X., Li, Y., Kim, B. J., Jia, J., Huang, Z., Yang, T., Fu, X., Jung, S. Y., Wang, Y., Zhang, P., Kim, S. T., Pan, X., and Qin, J. (2008). Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol. Cell 31, 143-151.

Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A.C., Mao, Y., Miao, R.Q., Sessa, W.C., Qin, J., Zhang, P., Bing Su, B., and Jacinto, E. (2008). The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 27, 1932-1943.

Huang X, Andreu-Vieyra CV, York JP, Hatcher R, Lu T, Matzuk MM, and Zhang, P. (2008). Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 6, e15.

Li, M., Shin, Y. H., Lin, F., Klann, E. and Zhang, P. (2008). The adaptor protein of the anaphase promoting complex Cdh1 plays an essential role in maintaining replicative life span and in learning and memory. Nat Cell Biol. 10, 1083-3089.

McMahon, A. P., Aronow, B. J., Davidson, D. R., Davies, J. A., Gaido, K. W., Grimmond, S., Lessard, J. L., Little, M.H., Potter, S. S., Wilder, E. L., and Zhang P. for the GUDMAP project. (2008). GUDMAP: The Genitourinary Developmental Molecular Anatomy Project. J Am Soc Nepherol 19: 667-71

Zhang, P. (2008). Transgenic RNA interference in mice. Methods in Mol. Biol. 442: 259-66.

Jia, J. and Zhang, P. (2008). Notch signaling and cell cycle control: striking the balance between proliferation and differentiation. Trends in Cell Cycle Research 2008, 143-154

Li, M., Fang, X., Wei, Z., York, J. P. and Zhang, P. (2009). Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J. Cell Biol. 185, 983-994.

Huang X, Andreu-Vieyra CV, Wang, M., Cooney, A., Matzuk MM, and Zhang, P. (2009) Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. Mol. Cell Biol. 29, 1498–1505

Li, M. and Zhang, P. (2009). The function of APC/C-Cdh1 in cell cycle and beyond. Cell Div. 4, 2-10. Li, M. and P. Zhang. (2009). Spindle assembly checkpoint, aneuploidy, and tumorigenesis. Cell Cycle 8, 3440.

Liang, Y., Gao, H., Lin, S.Y., Peng, G., Huang, X., Zhang, P, Goss, J. A., Brunicardi, F. C., Multani, A. S., Chang, S., and Li, K. (2010). BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 6: e1000826.

Chen, L., Guo, L., Tian, J., He, H., Marinova, E., Zhang, P., Zheng, B., and Han, S. (2010). Overexpression of CXC chemokine ligand 14 exacerbates collagen-induced arthritis. J. Immunol. 184: 4455-4459.

Chao WT, Ashcroft F, Daquinag AC, Vadakkan T, Wei Z, Zhang P, Dickinson M, and Kunz J. (2010). Type I PIP kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol. 30: 4463-79.

Li, M. Fang, X., Baker, D.J., Guo, L., Gao, X., Wei, Z., Han, S., van Derusen, J., and Zhang, P. (2010). The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis in mice. Proc Natl Acad Sci USA 107: 14188-93.G

ao, X., Shin, Y. H., Li, M., Wang, F., Tong, Q., and Zhang, P. (2010). The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE 5: e14005.

Peddibhotla, S., Wei, Z., Papineni, R., Lam, M.H., Rosen, J., and Zhang, P. (2011) The DNA damage checkpoint kinase 1 regulates the nucleolar shuttling of Cdc14B. Cell Cycle 10: 671-9.

Wei, Z., Peddibhotla, S., Lin, H., Fang, X., Li, M., Rosen, J. M., and Zhang, P. (2011). Early onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol. Cell Biol. 31: 1470-7.

Wei, Z. and Zhang, P. (2011). A phosphatase turns aggressive: the oncogenicity of CDC14B. Cell Cycle 10(15). PMID: 21734460.Wei, Z. and Zhang, P. (2011). Cdc14b: a player in aging. Aging 3:456. PMID: 21666283.

Fang, X. and Zhang, P. (2011). Aneuploidy and tumorigenesis. Semin. Cell Dev. Biol. 22(6): 595-601. PMID: 21392584.

Zhang, W., Peng, G., Lin, S. Y., and Zhang, P. (2011) DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J. Biol. Chem. 286(41): 35899-905. PMID: 21878640.

Chiu, H.S., York, J.P., Wilkinson, L., Zhang, P., Little, M.H., and Pennisi, D.J. (2012) Production of a mouse line with a conditional Crim1 mutant allele. Genesis 50: 711-6.

Shen, B., Zhang, J., Wu, H., Wang, J., Ma K, Li, Z., Zhang, X., Zhang, P, Huang X. (2013) Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res. 23:720-3.

O'Hara, L., York, J. P., Zhang, P., and Smith, L. B. (2014) Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives Cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice. PLoS ONE 9: e84541.

Fan, Y., Mao, R., Yu, Y., Liu, S., Shi, Z., Cheng, J., Zhang, H., An, L., Zhao, Y., Xu, X., Chen, Z., Kogiso, M., Zhang, D., Zhang, H., Zhang, P., Jung, J.U., Li, X., Xu, G., Yang, J. (2014) USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 211:313-28. PMID: 24493797

Huang, L., Belousova, T., Pan, J.S., Du, J., Ju, H., Lu, L., Zhang, P., Truong, L.D., Nuotio-Antar, A., and Sheikh-Hamad, D. (2014) AKI after Conditional and Kidney-Specific Knockdown of Stanniocalcin-1. J Am Soc Nephrol. 2014 Oct;25(10):2303-15. doi: 10.1681/ASN.2013070690. Epub 2014 Apr 3. PMID: 24700878 [PubMed - in process]

Zhang, Y., Berka, V., Song, A., Sun, K., Wang, W., Zhang, W., Ning, C., Li, C., Zhang, Q., Bogdanov, M., Alexander, D.C., Milburn, M.V., Ahmed, M.H., Lin, H., Idowu, M., Zhang, J., Kato, G.J., Abdulmalik, O.Y., Zhang, W., Dowhan, W., Kellems, R.E., Zhang, P., Jin, J., Safo, M., Tsai, A.L., Juneja, H.S., and Xia, Y. (2014) Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest. 2014 Jun 2;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16. PMID: 24837436 [PubMed - indexed for MEDLINE]

Hatcher, R. J., Dong, J., Liu, S., Bian, G., Zou, Q., Contreras, A., Wang, T., Hilsenbeck, S., Li, Y., and Zhang, P. (2014) Pttg1/Securin Is Required for the Branching Morphogenesis of the Mammary Gland and Suppresses Mammary Tumorigenesis. Proc Natl Acad Sci USA 111: 1008–1013.

Cheng, R., Peng, J., Yan, Y., Cao, P., Wang, J., Qiu, C., Tang, L., Liu, D., Tang, L., Jin, J., Huang, X., He, F., and Zhang, P. (2014) Efficient gene editing in adult mouse livers via adenoviral delivery of CRISPR/Cas9. FEBS Lett. 2014 Sep 19. pii: S0014-5793(14)00683-8. doi: 10.1016/j.febslet.2014.09.008. [Epub ahead of print]. PMID: 25241167